How many employees of large companies would like to move to smaller companies or start their own businesses? How many don't because they don't want to lose their "benefits", that is, health care insurance?
What happens if more employees feel free to start their own companies. Would they be competitors of their former employers, either directly or indirectly? If indirectly, would that be doing something that outdates what their former employers did?
Maybe large corporations don't like Federal healthcare because of perceived tax costs or because of increased power of the Federal government, power which would compete with or restrict their ability to do damn well what they please.
In other words, anything that reduces corporate power reduces the power of the oligarchy, the oligarchy that Publius warned about in Federalist No. 57 (see "When did we go wrong").