Two neuroscientists wrote an interesting article for the New York Times, "Mugged By Our Genes", 2009-03-24
They explore the relationship between genes and life experiences, noting some studies of identical twins and fraternal twins. The interesting comparison is that one identical twin may develop a certain destructive behaviour, such as alcoholism, and the other will develop a different behaviour that can lead to harm.
"[The] 'genes versus environment' debate is asking the wrong question. ... The evidence points to something more complex: genetic predispositions interact with circumstances to produce unique individuals."